The strength of Zymactive lies in its unique combination of proteolytic enzymes that break down proteins that cause inflammation and pain. These enzymes, including pancreatin, papain (derived from papaya), bromelain (sourced from pineapple stems), and Serratia peptidase exert anti-inflammatory effects that reduce damage to tissues. Serratia peptidase, also known as serrapeptase or the "miracle enzyme".

 Double Strength Zymactive systemic enzyme formula is more than twice as potent as other proteolytic enzyme supplements. The tablets are enteric coated to protect the proteolytic enzymes from being destroyed by stomach acid. The tablets are well tolerated and are not associated with any significant or uncomfortable side effects.